Gendepot/Angiopoietin-2, Human Recombinant Protein, CHO, CG1003/25 ug/CG1003-025,Gendepot,,Gendepot,Gen depot,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Gendepot/Angiopoietin-2, Human Recombinant Protein, CHO, CG1003/25 ug/CG1003-025

产品编号：CG1003-025

市场价：¥7200.00

场地：美国(厂家直采)

产品分类：抗体类>二抗>抗人>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$360.00

品牌： Gendepot

公司：Gendepot

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商品介绍

Source	CHO Cells
Formulation	0.22 µm filtered protein solution is in 20 mM MOPS, 150 mM NaCl, 5 mM CHAPS, and in pH 7.5.
Purity	>95%, as determined by Coomassie stained SDS-PAGE.
Biological Activity	When immobilized (1 µg/ml), Human ANGPT2 is able to bind to human Tie-2 in a dose dependent manner with an ED₅₀ of < 0.5="">
Stability	Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year. For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored at -20°C to -70°C. Stock solutions can also be prepared at 50 - 100 µg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2 - 1% BSA or HSA and stored in working aliquots at -20°C to -70°C.Avoid repeated freeze/thaw cycles.

Angiopoietin-2, also known as ANGPT2, is a member of angiopoietins, which plays essential roles in embryonic and postnatal angiogenesis. The structure of the mature form of ANGPT2 contains an N-terminal coiled-coil domain, which mediates multimerization of the protein, along with a C-terminal fibrinogen-like domain, which mediates the receptor binding. Both ANGPT1 and ANGPT2 are ligands for the receptor tyrosine kinase, Tie-2. ANGPT2 appears to exist predominantly as a homodimer, but it is also capable of forming multimers while ANGPT1 predominantly exists as multimers. It has been shown that ANGPT2 is able to promote vascular leakage and neutrophil migration. ANGPT2 can also sensitize TNF-α-induced monocyte adhesion, thus it is considered a proinflammatory factor. Although ANGPT2 is not required for arterial vascular development, its expression in the tissue suggests that it may play a role in the maintenance of these vessels. This conclusion is also supported by the observation that high concentrations of ANGPT2 activate the same survival signaling pathway as ANGPT1 to prevent endothelial cell apoptosis via Tie-2/Akt. Additionally, ANGPT2 was demonstrated to function as an agonist in the absence of ANGPT1, but in its presence it acts as an antagonist. Human ANGPT2 shares 86% amino acid sequence homology with its murine counterpart.

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GenDEPOT是一家领先的生物技术公司，致力于开发最有价值的生物研究产品。产品涵盖了生物学研究领域的各项创新技术。GenDEPOT的战略重点放在帮助研究人员改进他们的研究成果，降低成本，节省时间来完成他们的研究目标。此外，他们将通过不断改进我们的产品和服务，以满足我们的所有客户的需要。GenDEPOT产品包括细胞培养、细胞因子、生物检测试剂盒、核酸纯化、蛋白分离与分析、免疫印迹与免疫沉淀。

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