Gendepot/Paclitaxel, >99.5%, BC063/250mg/BC063-250,Gendepot,,Gendepot,Gen depot,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Gendepot/Paclitaxel, >99.5%, BC063/250mg/BC063-250

产品编号：BC063-250

市场价：¥4100.00

场地：美国(厂家直采)

产品分类：仪器类>电压电位>电生理设备>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$205.00

品牌： Gendepot

公司：Gendepot

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商品介绍

Assay	>99.5%
Solubility	DMSO: 50 mg/mL (can be stored frozen for several months)
Biochem/physiol Actions	Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Paclitaxel is an antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polyerization. Reversibly binds to polyerized tubulin.mInhibits protein isoprenylation and induces apoposis in PC-3 human prostatemcancer cells.

The checkpoint of mitotic spindle assembly, aberrant activation ofmcyclin-dependent kinases (CKDs) and the c-Jun N-terminal/stress activated protein

kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.

品牌介绍

GenDEPOT是一家领先的生物技术公司，致力于开发最有价值的生物研究产品。产品涵盖了生物学研究领域的各项创新技术。GenDEPOT的战略重点放在帮助研究人员改进他们的研究成果，降低成本，节省时间来完成他们的研究目标。此外，他们将通过不断改进我们的产品和服务，以满足我们的所有客户的需要。GenDEPOT产品包括细胞培养、细胞因子、生物检测试剂盒、核酸纯化、蛋白分离与分析、免疫印迹与免疫沉淀。

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