Gendepot/Cyclopamine, >99% , BC019/10 mg/BC019-010,Gendepot,,Gendepot,Gen depot,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Gendepot/Cyclopamine, >99% , BC019/10 mg/BC019-010

产品编号：BC019-010

市场价：¥2160.00

场地：美国(厂家直采)

产品分类：生化试剂>其他>胺>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$108.00

品牌： Gendepot

公司：Gendepot

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商品介绍

IC₅₀	46 nM in TM3Hh12 cells.
Biochem/physiol Actions	Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.
Solubility	10 mg/mL warmed (24.29 mM) in DMF2 mg/mL warmed (4.85 mM) in Ethanol

Cyclopamine inhibits the Hedgehog signaling pathway with an IC50 of 46 nM, and blocks the activity of human Smo receptor expressed in CHO-K1 cells in [3H]Hh-Ag binding assay with an IC₅₀of 280 nM.Cyclopamine significantly inhibits Hedgehog pathway activity in a dose-dependent manner in gut-derived tumor cell lines expressing Patched (PTCH) mRNA, and induces growth inhibition of those tumor cell lines by 75-95% at the concentration of 3 μM, but ineffective towards the colon tumor cells without PTCH mRNA expression, suggesting the effects of Cyclopamine treatment are Hedgehog pathway related rather than generally cytotoxic.By blocking Hedgehog signaling through direct interaction with Smo, Cyclopamine (10 μM) inhibits the proliferation of SMOhighCyclopamine-responsive cell lines L3.6sl and Panc 05.04 by 75-80%, and increases the apoptosis by 2.5- to 3.5-fold, without affecting the BxPC3-SMOlowcell line.Cyclopamine treatment significantly decreases of Snail mRNA and increasea E-cadherin transcripts in the E3LZ10.7 cell line. Independent of inhibition of cell growth, Cyclopamine treatment significantly inhibits the invasive phenotype of Hedgehog-dependent L3.6pl cells, causing a >500-fold reduction in the number of transmigrating cells, but not that of the Hedgehog-independent cell line Panc-1.

品牌介绍

GenDEPOT是一家领先的生物技术公司，致力于开发最有价值的生物研究产品。产品涵盖了生物学研究领域的各项创新技术。GenDEPOT的战略重点放在帮助研究人员改进他们的研究成果，降低成本，节省时间来完成他们的研究目标。此外，他们将通过不断改进我们的产品和服务，以满足我们的所有客户的需要。GenDEPOT产品包括细胞培养、细胞因子、生物检测试剂盒、核酸纯化、蛋白分离与分析、免疫印迹与免疫沉淀。

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