Gendepot/Ionomycin, Calcium Salt, >99%/10 mg/BC044-010,Gendepot,,Gendepot,Gen depot,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Gendepot/Ionomycin, Calcium Salt, >99%/10 mg/BC044-010

产品编号：BC044-010

市场价：¥4900.00

场地：美国(厂家直采)

产品分类：生化试剂>其他>盐>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$245.00

品牌： Gendepot

公司：Gendepot

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商品介绍

Target	Calcium channel
Solubility	DMSO : 200 mg/mL Ethanol : 10 mg/mL (14.10 mM)

Ionomycin is a Calcium ionophore and an antibiotic produced byStreptomyces conglobatusATCC 31005. It is observed that LCLC 103H cells overexpressing the catalytic subunit of μ-calpain rapidly underwent cell death after treatment with ionomycin. The first signs of Ionomycin-induced cell death are detected 3 h after addition of the ionophore. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca²⁺concentration from 50 to 180 nM. Remarkably, calcium concentrations are raised transiently to 0.8-1.5 μM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.

品牌介绍

GenDEPOT是一家领先的生物技术公司，致力于开发最有价值的生物研究产品。产品涵盖了生物学研究领域的各项创新技术。GenDEPOT的战略重点放在帮助研究人员改进他们的研究成果，降低成本，节省时间来完成他们的研究目标。此外，他们将通过不断改进我们的产品和服务，以满足我们的所有客户的需要。GenDEPOT产品包括细胞培养、细胞因子、生物检测试剂盒、核酸纯化、蛋白分离与分析、免疫印迹与免疫沉淀。

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